Mammalian mitoribosomes revealed
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چکیده
منابع مشابه
Mitoribosomes from Candida Utilis
Highly purified mitochondrial ribosomes (mitoribosomes) have been obtained from the yeast Candida utilis. Sedimentation analysis in sucrose gradients made in 5 mM MgCl(2), 1 mM Tris, pH 7.4 and 50 mM KCl clearly distinguishes mitoribosomes (72S) from cytoplasmic ribosomes (cytoribosomes) (78S). Mitoribosomes are completely dissociated into 50S and 36S subunits at 10(-4)M MgCl(2) whereas complet...
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The ribosome is an ancient ribonucleoprotein machine universally responsible for catalyzing protein synthesis. Within eukaryotic cells, mitochondria contain their own ribosomes (mitoribosomes), which are highly modified ribosomes of bacterial descent, specialized for the synthesis of a handful of proteins, all essential for the biogenesis of the oxidative phosphorylation system. With high-resol...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2015
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.3027